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. 2004 Jan 23;32(2):477–487. doi: 10.1093/nar/gkh214

Figure 4.

Figure 4

Alternatively spliced transcripts of the Mutyh gene encode two different forms of mMUTYH proteins. (A) Two forms of mMUTYH protein encoded by type b and c Mutyh mRNAs. The functional motifs in mMUTYHα encoded by type a and b mRNAs and mMUTYHβ encoded by type c mRNA are shown in the middle part. mMUTYHβ lacks the DNA minor groove reading motif (black box) present in mMUTYHα (25). An initiation codon (AUG, short bar) and stop codons (long bar) in each three reading frames (1, 2, 3) of type b and type c Mutyh mRNAs are shown in the upper (type b), and the lower part (type c). ORF, open reading frame for each mRNA. (B) The amino acid sequences of mMUTYHα and mMUTYHβ proteins. Differences in the amino acid sequences between the two MUTYH proteins are shown in bold. In MUTYHα, the common sequences with MUTYHβ are omitted (---). MTS-like sequences are underlined, while NLS-like sequences are shown in italic and are underlined. The boxed sequence in mMUTYHα indicates the DNA minor groove reading motif missing in mMUTYHβ.