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X-ray structure of human DHODH bound to C44 solved to 1.2 Å resolutions. The 4 Å shell around C44 is displayed, and the structure is aligned to the previously reported human DHODH structure complexed with brequinar (1D3G). The protein chain for the C44 structure is shown in orange, and the brequinar structure is shown in turquoise. The bound C44 and brequinar are shown as ball and stick. The bound FMN cofactor and the product orotate are also shown.
