Skip to main content
. 2013 Apr 24;4(6):517–521. doi: 10.1021/ml300464h

Table 1. SAR of the Right-Hand Aryl Ring.

graphic file with name ml-2012-00464h_0006.jpg

compd R EC50 (μM)a
brequinar see Figure 1 0.3
C1 O(CH2)2CH3 4.7
C2 OCH3 7.1
C3 OCH2CH3 5.7
C4 O(CH2)3CH3 6.3
C5 OCF3 0.5
C6 F 1.8
C7 Br 2.2
C8 CH3 8.7
C9 CH2CH3 5.7
C10 CF3 35.3
C11 OPh 1.3
a

Inhibition of VSV replication in MDCK epithelial cells.