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. 2013 Apr 24;4(6):517–521. doi: 10.1021/ml300464h

Table 2. SAR of the Left-Hand Ring.

graphic file with name ml-2012-00464h_0007.jpg

compd R1 R2 R3 EC50 (μM)a
C11 Cl H H 1.3
C12 F H H 0.1
C13 Br H H 3.1
C14 OCF3 H H 95.6
C15 OCH3 H H 2611
C16 NO2 H H 2.0
C17 CF3 H H 16.6
C18 H H H 1.0
C19 H H F 1.2
C20 H F H 158.8
C21 F F H 1.6
a

Inhibition of VSV replication in MDCK epithelial cells.