Table 4. DHODH Enzyme, VSV, and WSN Viral Growth Inhibition for Selected Analoguesa.
compd | DHODH IC50 (nM) | VSV EC50 (nM) | WSN EC50 (nM) |
---|---|---|---|
C1 | 260 | 4650 | 7600 |
C5 | 310 | 479 | NAb |
C6 | 1600 | 1770 | NA |
C8 | 5900 | 8650 | NA |
C12 | 36 | 110 | 1380 |
C11 | 95 | 1330 | 1884 |
C42 | 19 | 65 | 55 |
C43 | 16 | 23 | 71 |
C44 | 1 | 2 | 41 |
brequinar | 12 | 304 | 460 |
Assay conditions are described in the Supporting Information.
NA: not assayed.