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. 2013 Apr 24;4(6):517–521. doi: 10.1021/ml300464h

Table 4. DHODH Enzyme, VSV, and WSN Viral Growth Inhibition for Selected Analoguesa.

compd DHODH IC50 (nM) VSV EC50 (nM) WSN EC50 (nM)
C1 260 4650 7600
C5 310 479 NAb
C6 1600 1770 NA
C8 5900 8650 NA
C12 36 110 1380
C11 95 1330 1884
C42 19 65 55
C43 16 23 71
C44 1 2 41
brequinar 12 304 460
a

Assay conditions are described in the Supporting Information.

b

NA: not assayed.