TABLE 2.
MULTIVARIABLE MODEL USING GRADE 3 PGD AT DAY 2 OR 3 AS THE OUTCOME WITH CENTER AS A GROUPING VARIABLE
| Variable | Odds Ratio for PGD | 95% Confidence Interval | P Value |
| Transplant type | |||
| Bilateral | Reference | Reference | Reference |
| Single | 2.0 | 1.2–3.3 | 0.008 |
| Cardiopulmonary bypass use | 3.4 | 2.2–5.3 | <0.001 |
| Recipient sex | |||
| Male | Reference | Reference | Reference |
| Female without prior pregnancy | 0.9 | 0.4–2.0 | 0.9 |
| Female with one prior pregnancy | 0.6 | 0.2–1.9 | 0.4 |
| Female with two or more pregnancies | 1.3 | 0.9–2.1 | 0.2 |
| Recipient BMI | |||
| 18.5–25 | Reference | Reference | Reference |
| <18.5 | 1.3 | 0.6–2.8 | 0.6 |
| 25–30 | 1.8 | 1.2–2.7 | 0.01 |
| >30 | 2.3 | 1.3–3.9 | 0.004 |
| Total ischemic time per hour | 1.1 | 1.0–1.2 | 0.08 |
| Diagnosis | |||
| COPD | Reference | Reference | Reference |
| IPF | 1.2 | 0.8–1.9 | 0.3 |
| CF | 0.7 | 0.3–1.4 | 0.3 |
| Sarcoidosis | 2.5 | 1.1–5.6 | 0.03 |
| Pulmonary arterial hypertension* | 3.5 | 1.6–7.7 | 0.002 |
| PRBC transfusion | |||
| None | Reference | Reference | Reference |
| Up to 1L | 1.1 | 0.7–1.8 | 0.6 |
| >1L | 1.9 | 1.1–3.2 | 0.01 |
| mPAP per 10 mm Hg | 1.3 | 1.1–1.5 | <0.001 |
| Reperfusion FiO2 per 10% increase | 1.1 | 1.0–1.2 | 0.01 |
| Reperfusion FiO2 complete case analysis (n = 619) | 1.1 | 1.0–1.3 | 0.04 |
| Any donor smoking† | 1.8 | 1.2–2.6 | 0.002 |
| Donor smoking >20 pack-years† | 1.5 | 1.0–2.4 | 0.06 |
Definition of abbreviations: BMI = body mass index; CF = cystic fibrosis; COPD = chronic obstructive pulmonary disease; FiO2 = reperfusion fraction of inspired oxygen; IPF = idiopathic pulmonary fibrosis; mPAP = mean pulmonary artery pressure; PGD = primary graft dysfunction; PRBC = packed red blood cell transfusion volume.
*
The odds ratio for pulmonary arterial hypertension was determined using the full model in the absence of mPAP and bypass use given collinearity.
†
Two alternate determinations of donor smoking history were included in separate multivariable models.