Table 5.
Logistic regression analysis with ICU mortality as the dependent variable in patients with severe sepsis
| Univariate | Multivariatea | |||
|---|---|---|---|---|
| OR (95% CI) | P value | OR (95% CI) | P value | |
| Age (per year) | 1.03 (1.02 to 1.05) | < 0.001 | 1.03 (1 to 1.059) | 0.016 |
| Sex (female) | 2.01 (1.20 to 3.37) | 0.008 | 2.23 (1.17 to 4.24) | 0.014 |
| Comorbidities | ||||
| Diabetes mellitus | 0.79 (0.43 to 1.45) | 0.465 | ||
| Renal failure (with dialysis) | 0.21 (0.07 to 0.64) | 0.006 | 2.9 (0.68 to 12.45) | 0.151 |
| Renal failure (without dialysis) | 1.05 (0.52 to 2.15) | 0.887 | ||
| Heart failure (NYHA III to IV) | 0.96 (0.42 to 2.19) | 0.929 | ||
| COPD | 0.50 (0.19 to 1.28) | 0.147 | 1.75 80.58 to 5.32) | 0.319 |
| SAPS II (per point) | 1.04 (1.03 to 1.06) | < 0.001 | 1.03 (1.01 to 1.05) | 0.002 |
| Type of admission | ||||
| Elective surgery | R | NA | R | NA |
| Emergency surgery | 1.56 (0.64 to 3.84) | 0.330 | 1.09 (0.38 to 3.5) | 0.891 |
| Medical admission | 2.28 (0.95 to 5.43) | 0.064 | 1.7 (0.5 to 5.76) | 0.392 |
| Initial SOFA subscores | ||||
| SOFA respiratory | 1.53 (1.21 to 1.92) | < 0.001 | 1.65 (1.24 to 2.2) | 0.001 |
| SOFA hepatologic | 1.18 (0.96 to 1.45) | 0.110 | 1.25 (0.94 to 1.66) | 0.126 |
| SOFA hematologic | 1.32 (1.08 to 1.60) | 0.006 | 1.28 (0.99 to 1.65) | 0.059 |
| SOFA renal | 1.29 (1.07 to 1.54) | 0.006 | 0.92 (0.71 to 1.19) | 0.535 |
| SOFA neurologic | 1.097 (0.94 to 1.29) | 0.257 | ||
| SOFA cardiovascular | 1.272 (1.09 to 1.49) | 0.003 | 1.24 (1.02 to 1.51) | 0.034 |
| Referring facility | ||||
| Other hospital | R | NA | R | NA |
| Surgical ward | 0.2 (0.09 to 0.45) | < 0.001 | 5.17 (1.2 to 22.29) | 0.027 |
| Emergency department | 0.93 (0.28 to 3.1) | 0.913 | 3.53 (1.52 to 8.21) | 0.003 |
| Medical ward | 0.52 (0.26 to 1.05) | 0.068 | 1.43 (0.52 to 3.93) | 0.492 |
| Other ICU | 0.31 (0.15 to 0.63) | 0.001 | 4.87 (1.85 to 12.85) | 0.001 |
| Source of infection | ||||
| Pulmonary | 0.926 (0.586 to 1.465) | 0.743 | ||
| Abdominal | 0.542 (0.338 to 0.871) | 0.011 | 2.51 (1.15 to 5.44) | 0.02 |
| Renal | 1.697 (0.640 to 4.501) | 0.288 | ||
| Central nervous system | 0.833 (0.219 to 3.164) | 0.789 | ||
| Bone | 3.185 (0.328 to 30.965) | 0.318 | ||
| Soft tissue | 1.208 (0.427 to 3.417) | 0.722 | ||
Logistic regression analysis with ICU mortality as the dependent variable in patients with severe sepsis (n = 305). CI, confidence interval; COPD, chronic obstructive pulmonary disease; NA, not applicable; NYHA, New York Heart Association classification; OR, odds ratio; R, reference category; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment. aHosmer and Lemeshow χ2 = 10.543 (P = 0.229). Nagelkerke pseudo-R2 = 0.39.