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. 2013 Mar 15;187(6):648–657. doi: 10.1164/rccm.201205-0880OC

Figure 7.

Figure 7.

Functional impairment of CD34+ cells isolated from patients with pulmonary hypertension (PH) is corrected by diminazene aceturate (DIZE) treatment in vitro. (A) Migratory capacity of CD34+ cells isolated from patients with PH (n = 14) and age- and sex-matched control subjects (n = 6) in response to stromal-derived factor 1α (SDF-1α). Coincubation of CD34+ cells from patients with PH with 100 nM DIZE for up to 10 hours improved migration toward SDF-1α (n = 5) that was similar to the response observed with control cells. (B) Migration toward 100 nM angiotensin-(1–7) [Ang-(1–7)] was similar in cells from control subjects (n = 6) and patients with PH (n = 5). Data represent mean ± SEM. ***P < 0.001 compared with control cells or DIZE-treated normal control cells. #P < 0.05 compared with patients with PH.