Table 4.

Cox regression multivariable analysis of dermal Ki-67 positivity, dermal CD30 positivity, and stage at diagnosis (low vs. high) as dichotomous variables

	Variables remaining in model	p-value	Hazard ratio	95% confidence interval
Step 1*	Ki-67 dermis	0.005	9.80	1.97–48.89
	CD 30 dermis	0.036	3.79	1.09–13.13
	Stage at diagnosis	0.593	1.36	0.44–4.21
Step 2**	Ki-67 dermis	0.004	10.1	2.06–49.41
	CD 30 dermis	0.027	4.02	1.18–13.75

^*Dermal Ki-67 and dermal CD30 were chosen for multivariable analysis based on their strong statistical significance in univariate analysis and relative ease in application to routine clinical practice, compared to assessment of epidermal positivity. Stage at diagnosis was chosen based on its well-established role in prognostication of mycosis fungoides, as also identified in this study.

^**After use of backward stepwise selection method, only dermal Ki-67 and dermal CD30 remained as independent predictors of survival.