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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Bioorg Med Chem. 2013 Apr 6;21(11):2988–2998. doi: 10.1016/j.bmc.2013.03.074

Figure 4. Structural alignment of 11b and WC-10 as they occupy the D2 and D3 dopamine receptor binding sites.

Figure 4

Compounds 11b (shown in cyan) and the piperazine analogue WC-10 (shown in magenta) as they occupy the binding sites of A) the human dopamine D2 receptor and B) the human D3 dopamine receptor. The compounds sit much deeper in D3 than in D2 and overall adopt a more linear orientation.