Table III.

Leukotriene pathway haplotypes.

Haplotype	Global p-value^†	SNPs										Haplotype Frequency			P-value^†
Haplotype	Global p-value^†	SNPs										Overall	Cases	Controls	P-value^†
*ALOX5AP Three-way haplotype^	0.003	1	2	3

		G	A	T								0.06	0.02	0.11	0.0009
		G	G	A								0.30	0.31	0.29	0.81
		G	G	T								0.45	0.43	0.46	0.85
		A	G	A								0.19	0.24	0.14	0.01

*ALOX5AP^*	0.02	1	2	3	4

HapA		A	T	G	A							0.066	0.109	0.022	0.0009
		G	T	G	C							0.316	0.149	0.109	0.48
		G	A	G	C							0.129	0.351	0.280	0.59
		G	A	A	C							0.049	0.099	0.142	0.47
		G	T	G	A							0.121	0.033	0.067	0.28
		G	A	G	A							0.319	0.260	0.380	0.07

*ALOX5AP^*	0.24	1	2	3	4

HapB		G	T	A	C							0.496	0.560	0.430	0.10
		G	A	G	C							0.105	0.187	0.214	0.86
		A	A	A	T							0.079	0.109	0.100	0.89
		G	A	A	C							0.201	NA	0.014	0.64
		G	T	A	T							0.006	0.076	0.079	0.42
		A	A	G	C							0.008	0.000	0.016	0.23
		A	A	A	C							0.105	0.068	0.146	0.03

*LTA4H^*	0.44	1	2	3	4	5	6	7	8	9	10

HapK		C	G	T	G	A	T	T	C	G	G	0.027	0.070	NA	0.15
		T	G	T	G	G	C	G	T	A	G	0.025	0.039	NA	0.22
		C	G	T	A	A	T	T	T	A	A	0.014	0.017	0.011	0.25
		C	G	T	G	A	C	G	C	G	G	0.008	NA	NA	0.28
		C	G	C	G	A	T	T	T	A	G	0.006	0.012	NA	0.34
		C	G	C	G	A	T	G	C	G	A	0.006	0.011	NA	0.38
		C	G	T	G	A	C	T	T	A	G	0.012	0.019	NA	0.44
		C	G	T	G	A	C	T	T	G	G	0.020	0.023	0.024	0.58
		T	G	T	G	G	C	G	C	G	G	0.058	0.076	0.064	0.59
		T	A	T	G	A	C	G	T	A	A	0.104	0.108	0.100	0.74
		T	G	T	G	G	C	G	T	A	A	0.050	0.054	0.046	0.76
		C	G	T	A	A	T	T	T	A	G	0.032	0.035	0.000	0.82
		C	G	T	G	A	T	T	T	G	G	0.324	0.324	0.312	0.93
		C	G	T	G	A	C	T	C	G	G	0.012	NA	0.022	0.91
		C	G	C	G	A	T	G	T	A	G	0.006	NA	0.013	0.71
		C	G	T	G	A	T	T	T	A	G	0.062	0.054	0.080	0.60
		C	G	T	A	A	T	T	C	G	G	0.006	NA	0.011	0.57
		C	G	T	A	A	T	T	C	A	G	0.028	0.000	0.028	0.55
		C	G	C	G	A	C	T	T	G	G	0.006	NA	0.011	0.44
		C	A	T	G	A	C	G	T	A	A	0.158	0.142	0.188	0.36
		T	G	T	G	A	T	T	T	A	G	0.006	NA	0.011	0.31
		C	G	C	G	A	T	G	T	A	A	0.025	NA	0.046	0.01

Three-way haplotype composed of the individually associated ALOX5AP SNPs (rs17216473, rs17222814, rs10507391).

^†

Adjusted for hypertension, dyslipidemia, diabetes, smoking, BMI and CADindex.

^**

ALOX5AP (HapA): rs17222814 (1), rs10507391 (2), rs476874 (3), rs9551963 (4)

ALOX5AP (HapB): rs17216473 (1), rs10507391 (2), rs9315050 (3), rs17222842 (4)

LTA4H (HapK): 12p0557 (1), rs2660880 (2), rs6538697 (3), rs1978331 (4), rs17677715 (5), rs2247570 (6), rs2660898 (7), rs2540482 (8), rs2660845 (9), rs2540475 (10)

NA: numbers too small to converge on estimate