. Author manuscript; available in PMC: 2013 Aug 5.

Published in final edited form as: Leukemia. 2012 Aug 20;27(3):740–743. doi: 10.1038/leu.2012.239

Table 2.

Ten out of 20 most downregulated genes in NOTCH1-mutated samples have known tumor suppressor or pro-apoptotic function.

Gene name	Reference	P-value	FC	Function
CDKN1A	Harper et al.⁹	0.00457	2.43	Tumor suppressor
FOS	Pekarsky et al.⁸	0.00589	3.62	Pro-apoptotic
FOSB	Pekarsky et al.⁸	0.01604	6.56	Pro-apoptotic
DUSP10	Tanoue et al.¹¹	0.02811	2.30	Anti-proliferative
IFIT2	Stawowczyk et al.¹²	0.03051	2.19	Tumor suppressor
NR4A3	Mullican et al.¹⁰	0.03151	2.52	Pro-apoptotic
EGR1	Huang et al.¹³	0.03359	3.60	Pro-apoptotic
KLF4	Shields et al.¹⁴	0.03436	3.01	Anti-proliferative
FOSL2	Pekarsky et al.⁸	0.03591	2.10	Pro-apoptotic
IFIT3	Xiao et al.¹⁵	0.05028	3.08	Anti-proliferative

Abbreviation: FC, fold change.