Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A model describing the regulation of eNOS-TLR4-NFκB signaling by caveolin-1. Caveolin-1 is a critical negative regulator of eNOS via direct interaction. Caveolin-1 deficiency leads to eNOS translocation and activation, resulting in IRAK4 nitration. IRAK4 nitration inhibits TLR4 signaling in response to LPS challenge. Impaired TLR4 signaling results in dampening of the inflammatory response through decreased NFκB activation.
