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. Author manuscript; available in PMC: 2013 Aug 5.
Published in final edited form as: Blood Rev. 2010 Apr 24;24(3):101–122. doi: 10.1016/j.blre.2010.03.002

Figure 7.

Figure 7

FA/BRCA DNA damage response pathway. Following DNA damage, the proteins represented by A, B, C, E, F, G, L, and M form the core complex, which is required for ubiquitination of the I and D2 proteins, which are in turn required for the downstream complex of D2-ubi, I-ubi, and D1/BRCA2, N/PALB2, BRCA1, and J/BACH1/BRIP1 to form foci for DNA repair. Only BRCA1 is not yet known to be a Fanconi gene.