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. 2008 Dec 3;28(49):13248–13257. doi: 10.1523/JNEUROSCI.3027-08.2008

Figure 5.

Figure 5.

Inhibition of ERK and CREB phosphorylation in the central amygdala decreased morphine CPP after 14 withdrawal days. A, B, Central (CeA) but not basolateral (BLA) amygdala injections of U0126 decreased morphine (3 mg/kg) CPP. Data are the mean ± SEM of preference score in seconds during the CPP preference tests conducted 14 d after withdrawal from morphine. *p < 0.05, different from the vehicle condition. C, E, Central amygdala U026 injections decreased ERK and CREB phosphorylation in the central but not basolateral amygdala. D, F, Basolateral amygdala U026 injections decreased ERK and CREB phosphorylation in the basolateral but not central amygdala. Data are presented as a percentage of the respective vehicle groups. *p < 0.05, different from the vehicle group within each amygdala sub-nucleus (n = 7–8 per group).