Table 3. Effect of selected compounds on viability of MDA-MB-231/R and MDA-MB-231/V cellsa.
| Compound | % Viability | |||
|---|---|---|---|---|
| MDA-MB-231/R | MDA-MB-231/V | |||
| 10 μM | 5 μM | 10 μM | 5 μM | |
| A-1 | 122 (9) | NDb | 101 | ND |
| A-2 | 32 (4)c | 35 (7) | 37 (3)c | 65 (19) |
| A-3 | 65 (4)c | 82 (7) | 86 (4)c | 90 (2) |
| DA-1 | 56 (7)c | 59 (6)d | 108 (10)c | 108 (8)d |
| UA-1 | 60 (8)c | 68 (10)d | 103 (7)c | 98 (9)d |
| IA-1 | 68 (6)c | 91 (10)d | 97 (8)c | 102 (6)d |
| HA-1 | 77 (21)c | 88 (24) | 108 (4)c | 112 (7) |
| AZ-1 | 93 (9) | 101 (15) | 110 (3) | 111 (7) |
| I-1 | 94 (10) | 92 (10) | 108 (5) | 109 (14) |
| I-2 | 61 (10)c | 65 (14) | 93 (4)c | 100 (9) |
| I-3 | 73 (13) | 83 (10) | 101 (5) | 109 (13) |
| F-1 | 70 (3)c | 94 (16) | 97 (3)c | 105 (6) |
| F-2 | 68 (4)c | 88 (6) | 88 (1)c | 101 (3) |
| F-3 | 63 (16) | 76 (13) | 91 (4) | 103 (6) |
| C-1 | 75 (4)c | 112 (23) | 92 (3)c | 103 (4) |
| C-2 | 75 (14) | 71 (2)d | 84 (3) | 90 (2)d |
| C-3 | 71 (12) | 84 (4) | 89 (1) | 92 (6) |
a
Percentage viability = (Average absorbance of wells with test compounds / Average absorbance of control wells with medium and 1% DMSO) × 100%. Values are mean (SD) of three independent determinations.
b
ND = Not detected.
c
Significant difference (p< 0.05) between % viability of R cells and V cells at 10μM by paired t test (2-sided).
d
Significant difference (p< 0.05) between % viability of R cells and V cells at 5μM by paired t test (2-sided).