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. Author manuscript; available in PMC: 2013 Nov 30.
Published in final edited form as: Cell Rep. 2013 May 16;3(5):1346–1354. doi: 10.1016/j.celrep.2013.04.014

Figure 2. TCF3/E2A and TRIAP1 control the p21:PUMA expression ratio in diverse cancer cell types.

Figure 2

A. Western blot and Q-RT-PCR assays show that TCF3/E2A functions as a coactivator of p21 expression and a repressor of PUMA expression in HCT116 colorectal carcinoma cells and U2OS osteosarcoma cells. See Figure S2 for data on A549 lung carcinoma cells B. TRIAP1 functions as a gene-specific repressor of p21. C,D. Q-RT-PCR analysis showing the effects of TCF3/E2A and TRIAP1 knockdown on diverse p53 target genes. All Q-RT-PCR experiments are expressed as averages of three biological replicates −/+ s.d. See also Figure S2.

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