Table 1.
Target profile | South Asia | Africa |
---|---|---|
Risk:Benefit |
Must be very high Parasitological cure must be achieved |
No direct associated mortality with symptomatic treatment |
Ease of use |
|
Feasible to use at the level of a health clinic |
Course of treatment |
Very short course of treatment to facilitate compliance |
Minimum acceptable treatment for children: one week (similar to antibiotics) |
Cold chain requirements |
Ideally not cold chain dependent |
|
Cost factors |
Cost is less important than commitment to treatment |
|
Concomitant infections | With HIV co-infection, no antimonials or monotherapies |