Table 1.

Fitting parameters for the kinetic model of S. cerevisiae metabolic network

Parameter	Comment	Valuea
		3-ATb	WOAc
α	Kinetic order for biomass drain fluxes	1.00×10-1	1.00×10-1
βd	Ratio of the forward (or backward if reference flux is negative) reaction rate	3.00×101	3.00×101
	to the overall rate of the reversible reactions
γ	Correction factor for biomass growth rate	9.80×10-1	1.00×100
kser→gly	Inhibition factor of the synthesis of glycine from serine by 3-AT	2.27×10-2	-
khis	Inhibition factor of the synthesis of histidine 3-AT	4.87×10-1	-
rWOA	WOA uptake rate	-	3.00×101

^a All parameters are dimensionless.

^b Parameter values for simulating the response of S. cerevisiae to 3-aminotriazole (3-AT).

^c Parameter values for simulating the response of S. cerevisiae to weak organic acids (WOA).

^d Reversibility of the reactions was based on the designations in the model by Moxley et al. [25] and the KEGG database (http://www.genome.jp/kegg/).