Table 2.

Predicted targets of 3-aminotriazole in the S. cerevisiae central carbon metabolic network

Reaction indexa	Reaction	Normalized SSEb
46	SER ↔ GLY + METTHF (forward)	0.50
46	SER ↔ GLY + METTHF (backward)	0.53
79	R5P + METTHF + 2 ATP → IAP	0.56
91	HIS + ATP → HISBIO	0.60
80	IAP + GLU → HIS + AKG + 2 NADH	0.71
6	G3P ↔ PEP + NADH + ATP (forward)	0.71
6	G3P ↔ PEP + NADH + ATP (backward)	0.71
41	NADH → ATP	0.72
53	HSER + METTHF + ACCOA + 2 ATP → MET + ACE + 3 NADH	0.72
95	MET + ATP → METBIO	0.72

^a See Additional file 3 for details about the reactions and abbreviations.

^b The sum of squared errors (SSE) was normalized with the SSE of a simulation without perturbing any reaction.