Table 3.
Thrombin generation test
| TGT | Controls (n = 24) | DF without bleeding (n = 9) | DF with bleeding (n = 9) | P # |
|---|---|---|---|---|
| Lag phase * |
9.1 (1.8-17.7) |
12.3 (3.1 -17.1) ± |
11.6 (3.1 – 22.6) ± |
0.021 |
| Thrombin peak (nM) * |
338.7 (145.1 - 512.2) |
251.6 (70.7 – 432.3) |
199.0 (15.9 – 394.1) ± |
0.009 |
| Velocity-index * |
59.1 (13.3 – 128.7) |
37.3 (6.7 – 193.2) |
32.8 (12.6-73.0) ± |
0.033 |
| AUC * | 3753.4 (2228.9–4905.6) | 3367.5 (1512.9-4284.2) | 2274.5 (180.5-3829.2) ± | 0.002 |
* Median and range.
# P values were calculated using the Kruskal-Wallis analysis.
± Tukey test detected places of differences. In lag phase the differences were in DF with and also in DF without bleeding vs. controls. In thrombin peak, velocity index and AUC the difference was significant in the DF with bleeding group vs. controls.
This table shows the TGT results in controls and patients with DF, according to the presence of bleeding manifestations.