Table 1. Characteristics of included studies.
| NO. | Author | Year | Country | Number of Patients | Organ | Duration of Follow-up | Methods | Staining patterns | Cut off scores (pos/neg) | T category (T1–2/3–4) | N category (P/N) | Distant metastasis(M0/M1) | Grade (1–2/3) | OS (5 years) |
| 1 | Tachezy | 2012 | germany | 192 | pancretic CA | 0–193 months (median 14 months) | TMA | membrane staining | membrane staining positive(72/120) | H(105/15); L(65/7) | NA | NA | H(68/52); L(38/34) | H(29/91); L(6/66)* |
| 2 | Tachezy | 2011 | germany | 38 | pancretic neuroendocrine CA | 7–168 months (median 45 months) | TMA | membrane staining | 2+ >30% and 3+ (28/10) | NA | NA | H(4/23);L(5/5) | H(26/2); L(9/1) | H (23/51);L (3/7)* |
| 3 | Kahlert | 2009 | germany | 97 | pancretic CA | median 18.5 months | whole tissue | membrane and cytoplasmic staining | membrane and cytoplasmic staining (30/67) | H(6/24); L(12/55) | H(6/24); L(12/55) | NA | H(15/15); L(46/21) | H (0/30) L(19/48)* |
| 4 | Tachezy | 2012 | germany | 289 | esophageal CA | 0–178 months (median 16 months) | TMA | membrane staining | 1+ >30% or≥2+ (204/85) | H(87/117); L(35/50) | H(75/129); L(26/59) | H(166/38); L(72/13) | H(128/76); L(39/46) | H (43/163) L(30/55)* |
| 5 | Ishigami | 2011 | japan | 142 | gastric cancer | 0.3–104.5 months (median 18.6 months) | whole tissue | membrane and cytoplasmic staining | membrane and cytoplasmic staining (36/106) | H(28/8); L(79/27) | H(23/13); L(41/65) | NA | NA | H (20/16) L (71/35)* |
| 6 | weichert | 2004 | germany | 111 | colorectal CA | median 47 months | whole tissue | membrane and cytoplasmic staining | membrane and cytoplasmic staining (34/77) | NA | NA | NA | NA | H (20/14) L (61/16)* |
| 7 | Horst | 2009 | germany | 110 | colorectal CA | 4.8–162 months (median 94.8 months) | TMA | membrane staining | membrane staining positive (70/40) | H(22/48); L(17/28) | H(12/54); L(7/33) | NA | H(63/7); L(36/4) | H (42/28) L (33/7)* |
| 8 | Lugli | 2010 | switzerland | 1274 | colorectal CA | 0–80 months | TMA and whole tissue | membrane staining | membrane staining positive (775/499) | H(165/594); L(72/417) | H(417/329); L(228/253) | H(275/63); L(70/18) | H(658/100); L(438/49) | H (465/310) L (274/225) |
| 9 | Tachezy | 2012 | germany | 300 | colorectal CA | 1–180 months (median 39 months) | TMA | membrane staining | membrane staining positive (229/71) | H(59/170); L(14/57) | H(115/114); L(31/40) | H(168/61); L(53/18) | H(200/29); L(50/21) | H (135/94); L(26/45)* |
CA: cancer; H: high expression; L: low expression; NA:not available; TMA: tissue microarray.
*
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