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. 2013 Aug 5;8(8):e70917. doi: 10.1371/journal.pone.0070917

Table 3. Univariable and multivariable comparisons of clinical and ultrasound risk factors for All SGA by customised birthweight centiles.

Training Cohort
N = 3735 N = 3541
Risk Factors SGA Non SGA Univariable Odds Ratio (95% CI) Multivariable Odds Ratio (95% CI) Multivariable Odds Ratio (95% CI)††
N = 422 N = 3313
15 week data AUC = 0.66 AUC = 0.73
Family history of coronary heart disease (father) 72 (17.1) 402 (12.1) 1.49 (1.13 to 1.96) 1.46 (1.10 to 1.93) 1.63 (1.22, 2.19)
Maternal birthweight (grams)* 3163 (539) 3329 (559)
<3000 138 (35%) 749 (24%) 2.18 (1.66 to 2.86) 2.09 (1.60 to 2.74) 1.98 (1.49, 2.63)
3000–3499 157 (40%) 1212 (38%) 1.53 (1.17 to 1.99) 1.56 (1.21 to 2.02) 1.56 (1.19, 2.05)
≥3500 100 (25%) 1183 (38%) 1.00 1.00 1.00
>12 months to conceive 89 (21%) 526 (16%) 1.42 (1.10 to 1.82) 1.48 (1.14 to 1.91) 1.36 (1.03, 1.78)
Currently attending university 20 (5%) 88 (3%) 1.82 (1.12 to 3.00) 1.91 (1.14 to 3.19) 1.87 (1.08, 3.24)
Currently smoking 81 (19%) 331 (10%) 2.14 (1.64 to 2.80) 2.15 (1.63 to 2.83) 2.13 (1.59, 2.84)
Proteinuria 28 (7%) 126(4%) 1.80 (1.18 to 2.74) 1.61 (1.04 to 2.50) 1.57 (0.99, 2/49)
Vigorous exercise ≥1 x/day 12 (3%) 29 (0.9%) 3.33 (1.69 to 6.57) 3.78 (1.87 to 7.66) 3.22 (1.43, 7.29)
Diastolic BP≥80 mmHg 39 (9%) 176 (5%) 1.82 (1.26 to 2.61) 1.84 (1.27 to 2.68) 1.82 (1.21, 2.73)
Recreational walking ≥4 x/week 69 (17%) 701 (21%) 0.73 (0561 to 0.96) 0.72 (0.55 to 0.96) 0.73 (0.55, 0.98)
Rhesus negative blood group 41(10%) 512 (15%) 0.59 (0.42 to 0.82) 0.58 (0.41 to 0.81) 0.60 (0.42, 0.85)
Random glucose per unit increase 5.2 (0.9) 5.3 (1.0) 0.87 (0.78 to 0.98) 0.85 (0.76 to 0.95) 0.84 (0.75, 0.95)
20 week scan data †† N = 401 N = 3174
Head circumference z score <10th centile** 66 (17%) 267 (8%) 2.14 (1.60 to 2.87) 1.79 (1.30 to 2.46)
Abdominal circumference z score <10th centile*** 64 (16%) 278 (9%) 1.98 (1.47 to 2.65) 1.73 (1.25 to 2.39)
Average uterine resistance index 0.61 (0.10) 0.56 (0.10)
<0.5 57 (14%) 844 (26%) 1.0 1.0
0.5 to 0.59 111 (28%) 1259 (40%) 1.31 (0.94 to 1.82) 1.31 (0.93 to 1.84)
0.6 to 0.69 151 (38%) 752 (24%) 2.97 (2.16 to 4.10 ) 2.80 (2.01 to 3.90)
0.7 to 0.79 65 (16%) 259 (8%) 3.72 (2.54 to 5.44) 3.63 (2.44 to 5.39)
0.8 to 1.0 17 (4%) 60 (2%) 4.20 (2.30 to 7.66) 4.56 (2.45 to 8.48)

Data are mean (SD) number (%) as appropriate, italics indicate variable is protective.

*

missing data numbers for woman’s birthweight (SGA n = 27, no SGA 169 missing.

**

missing data numbers for head circumference z score <10th centile (SGA n = 2, no SGA n = 23 missing).

***

missing data numbers for abdominal circumference z score <10th centile (SGA n = 1, no SGA n = 12 missing).

Unimputed data was used for univariable analyses.

††

Unimputed ultrasound data was added to the multivariable models derived from 15 week imputed data.