Table 3. Univariable and multivariable comparisons of clinical and ultrasound risk factors for All SGA by customised birthweight centiles.
Training Cohort | |||||
N = 3735 | N = 3541 | ||||
Risk Factors | SGA | Non SGA | Univariable Odds Ratio (95% CI)† | Multivariable Odds Ratio (95% CI) | Multivariable Odds Ratio (95% CI)†† |
N = 422 | N = 3313 | ||||
15 week data | AUC = 0.66 | AUC = 0.73 | |||
Family history of coronary heart disease (father) | 72 (17.1) | 402 (12.1) | 1.49 (1.13 to 1.96) | 1.46 (1.10 to 1.93) | 1.63 (1.22, 2.19) |
Maternal birthweight (grams)* | 3163 (539) | 3329 (559) | |||
<3000 | 138 (35%) | 749 (24%) | 2.18 (1.66 to 2.86) | 2.09 (1.60 to 2.74) | 1.98 (1.49, 2.63) |
3000–3499 | 157 (40%) | 1212 (38%) | 1.53 (1.17 to 1.99) | 1.56 (1.21 to 2.02) | 1.56 (1.19, 2.05) |
≥3500 | 100 (25%) | 1183 (38%) | 1.00 | 1.00 | 1.00 |
>12 months to conceive | 89 (21%) | 526 (16%) | 1.42 (1.10 to 1.82) | 1.48 (1.14 to 1.91) | 1.36 (1.03, 1.78) |
Currently attending university | 20 (5%) | 88 (3%) | 1.82 (1.12 to 3.00) | 1.91 (1.14 to 3.19) | 1.87 (1.08, 3.24) |
Currently smoking | 81 (19%) | 331 (10%) | 2.14 (1.64 to 2.80) | 2.15 (1.63 to 2.83) | 2.13 (1.59, 2.84) |
Proteinuria | 28 (7%) | 126(4%) | 1.80 (1.18 to 2.74) | 1.61 (1.04 to 2.50) | 1.57 (0.99, 2/49) |
Vigorous exercise ≥1 x/day | 12 (3%) | 29 (0.9%) | 3.33 (1.69 to 6.57) | 3.78 (1.87 to 7.66) | 3.22 (1.43, 7.29) |
Diastolic BP≥80 mmHg | 39 (9%) | 176 (5%) | 1.82 (1.26 to 2.61) | 1.84 (1.27 to 2.68) | 1.82 (1.21, 2.73) |
Recreational walking ≥4 x/week | 69 (17%) | 701 (21%) | 0.73 (0561 to 0.96) | 0.72 (0.55 to 0.96) | 0.73 (0.55, 0.98) |
Rhesus negative blood group | 41(10%) | 512 (15%) | 0.59 (0.42 to 0.82) | 0.58 (0.41 to 0.81) | 0.60 (0.42, 0.85) |
Random glucose per unit increase | 5.2 (0.9) | 5.3 (1.0) | 0.87 (0.78 to 0.98) | 0.85 (0.76 to 0.95) | 0.84 (0.75, 0.95) |
20 week scan data †† | N = 401 | N = 3174 | |||
Head circumference z score <10th centile** | 66 (17%) | 267 (8%) | 2.14 (1.60 to 2.87) | 1.79 (1.30 to 2.46) | |
Abdominal circumference z score <10th centile*** | 64 (16%) | 278 (9%) | 1.98 (1.47 to 2.65) | 1.73 (1.25 to 2.39) | |
Average uterine resistance index | 0.61 (0.10) | 0.56 (0.10) | |||
<0.5 | 57 (14%) | 844 (26%) | 1.0 | 1.0 | |
0.5 to 0.59 | 111 (28%) | 1259 (40%) | 1.31 (0.94 to 1.82) | 1.31 (0.93 to 1.84) | |
0.6 to 0.69 | 151 (38%) | 752 (24%) | 2.97 (2.16 to 4.10 ) | 2.80 (2.01 to 3.90) | |
0.7 to 0.79 | 65 (16%) | 259 (8%) | 3.72 (2.54 to 5.44) | 3.63 (2.44 to 5.39) | |
0.8 to 1.0 | 17 (4%) | 60 (2%) | 4.20 (2.30 to 7.66) | 4.56 (2.45 to 8.48) |
Data are mean (SD) number (%) as appropriate, italics indicate variable is protective.
missing data numbers for woman’s birthweight (SGA n = 27, no SGA 169 missing.
missing data numbers for head circumference z score <10th centile (SGA n = 2, no SGA n = 23 missing).
missing data numbers for abdominal circumference z score <10th centile (SGA n = 1, no SGA n = 12 missing).
Unimputed data was used for univariable analyses.
Unimputed ultrasound data was added to the multivariable models derived from 15 week imputed data.