Skip to main content
. Author manuscript; available in PMC: 2013 Dec 20.
Published in final edited form as: Neuron. 2012 Dec 20;76(6):1078–1090. doi: 10.1016/j.neuron.2012.12.004

Figure 7. Cortical Circuits Are Developmentally Disrupted in the Absence of Mecp2.

Figure 7

Parvalbumin (PV) intensity and puncta density onto pyramidal cells reveal a PV-circuit hyperconnectivity as early as P15 that increases throughout life, while GAD65 is not downregulated until adulthood. Circuit-based therapeutic strategies independent of Mecp2 may now be relevant. An effective strategy to prevent the delayed loss of cortical functions (such as vision or language) should focus on early interventions to dampen PV hyperconnectivity (A) rather than on acute enhancement of inhibition once regressive symptoms have emerged (B). See also Figure S4.