Table 5.
Blood parameter, treatment dose and variability (MSSD) of Period 1–2 vs. Period 3–4, Darbepoetin alfa
| Darbepoetin alfa |
Period 1–2 |
Period 3–4 |
p-value |
|---|---|---|---|
| (n = 19) | (n = 19) | ||
|
Hemoglobin, g/dl (mean, SD) |
11.0 (0.9) |
11.4 (0.7) |
0.15 |
|
Reticulocyte count, cells/μl (mean, SD) |
67543 (19668) |
72766 (18220) |
0.41 |
|
Ferritin, μg/l (mean, SD) |
465.9 (156.1) |
478.9 (98.3) |
0.76 |
|
Cumulated ESA dose, μg (mean, SD) |
1121.6 (744.6) |
865.6 (622.9) |
0.26 |
|
Cumulated iron dose, μg (mean, SD) |
705.6 (340.4) |
611.1 (286.7) |
0.37 |
|
ST-MSSD Hb, g2/dl2 (mean, SD) |
0.54 (0.35) |
0.67 (0.45) |
0.30 |
|
LT-MSSD Hb, g2/dl2 (mean, SD) |
0.28 (0.24) |
1.01 (1.24) |
0.02 |
|
ST-MSSD Ret, cells2/μl2 (mean, SD) |
48.4x108 (40.3x108) |
20.3x108 (20.5x108) |
0.01 |
|
LT-MSSD Ret, cells2/μl2 (mean, SD) |
2.0x108 (2.4x108) |
6.9x108 (9.7 x108) |
0.04 |
| LT-MSSD ESA, μg2 (mean, SD) | 1701 (2113) | 15650 (41055) | 0.07 |