Table 1.
Patient characteristics at the year 1 assessment: data is presented for all patients and sub-divided by exacerbation category in year 1 of follow-up
| All COPD (n=1832) | FE (n=543) | IE (n=1289) | p-value FE v IE | |
|---|---|---|---|---|
| Age (years) |
64 (7) |
64 (7) |
64 (7) |
0.751 |
| Females (%) |
35% |
41% |
32% |
<0.001 |
| BMI (kg/m2) |
27 (6) |
26 (6) |
27 (6) |
0.006 |
| Active smoker (%) |
36% |
33% |
37% |
0.113 |
| *FEV1 (L) |
1.37 (0.55) |
1.14 (0.45) |
1.47 (0.55) |
<0.001 |
| *FEV1 %predicted |
49 (16) |
43 (16) |
52 (16) |
<0.001 |
| *FEV1/FVC % |
45 (12) |
41 (12) |
46 (12) |
<0.001 |
| 6-minute walk distance (m) |
385 (123) |
350 (119) |
399 (122) |
<0.001 |
| %predicted 6MWD |
74 (24) |
69 (23) |
77 (23) |
<0.001 |
| Blood oxygen saturation (%) |
94.7 (2.9) |
94.2 (3.1) |
94.9 (2.8) |
<0.001 |
| Emphysema LAA% (-950HU) |
18 (12) |
20 (13) |
17 (12) |
<0.001 |
| mMRC Dyspnoea Score |
1.7 (1.1) |
2.0 (1.1) |
1.5 (1.0) |
<0.001 |
| SGRQ-C Total Score |
47 (21) |
57 (18) |
43 (21) |
<0.001 |
| BODE Index |
3.0 (2.1) |
3.9 (2.2) |
2.7 (2.0) |
<0.001 |
| White blood cells (10^9/L) |
7.6 (2.2) |
8.1 (2.4) |
7.4 (2.0) |
<0.001 |
| Platelets (10^9/L) |
266 (71) |
276 (75) |
261 (69) |
0.002 |
| Fibrinogen (mg/dL) |
436 [383–504] |
468 [405–535] |
426 [376–492] |
<0.001 |
| CRP (mg/dL) |
3.3 [1.5-7.3] |
4.1 [1.8-9.1] |
3.1 [1.4-6.6] |
<0.001 |
| SP-D (ng/mL) |
119 [87–163] |
115 [86–159] |
121 [87–166] |
0.294 |
| PARC/CCL-18 (ng/mL) |
112 [87–145] |
119 [92–154] |
111 [85–141] |
0.001 |
| Neutrophils (10^9/L) |
5.0 (1.9) |
5.4 (2.2) |
4.8 (1.8) |
<0.001 |
| Treated with ICSL % |
71% |
81% |
66% |
0.159 |
| Treated with LAMA % |
63% |
68% |
60% |
<0.001 |
| Treated with ICS % |
17% |
15% |
17% |
0.336 |
| Treated with LABA % |
14% |
14% |
15% |
0.813 |
| Treated with Oxygen % |
10% |
16% |
6% |
<0.001 |
| PPPY COPD Hosp. Year 1 |
0.20 |
0.55 |
0.05 |
<0.001 |
| PPPY OCS only exbs Y1 |
0.13 |
0.35 |
0.04 |
<0.001 |
| Diabetes |
10% |
8% |
10% |
0.287 |
| Cardiovascular (excl. HTN) |
33% |
32% |
33% |
0.868 |
| Reflux/heartburn |
26% |
33% |
23% |
<0.001 |
| Anxiety |
16% |
21% |
14% |
<0.001 |
| Depression symptoms | 25% | 33% | 21% | <0.001 |
P-values are for comparisons between patients with Frequent (FE) and Infrequent exacerbations (IE). Mean (SD) or Median [25% - 75% percentile].