Table 2.
Patient characteristics at year 1 assessment split by exacerbation phenotype over study years 1 and 2
|
Year 1 Category |
Year 1 IE (n=1289) |
Year 1 FE (n=543) |
||||
|---|---|---|---|---|---|---|
|
Year 2 Category |
Stayed as IE (n=1068) |
Change to FE (n=221) |
p-value |
Stayed as FE (n=333) |
Change to IE (n=210) |
p-value |
| Characteristics at Year 1 Assessment | ||||||
| Age (years) |
64 (7) |
64 (7) |
0.496 |
64 (7) |
65 (7) |
0.508 |
| Females (%) |
31% |
41% |
0.002 |
42% |
40% |
0.561 |
| BMI (kg/m2) |
27 (6) |
26 (5) |
0.007 |
26 (6) |
26 (5) |
0.918 |
| Active smoker (%) |
37% |
35% |
0.646 |
33% |
32% |
0.776 |
| *FEV1 (L) |
1.52 (0.56) |
1.23 (0.45) |
<0.001 |
1.09 (0.41) |
1.23 (0.50) |
<0.001 |
| *FEV1 %predicted |
53 (16) |
45 (15) |
<0.001 |
41 (15) |
46 (16) |
0.001 |
| *FEV1/FVC % |
47 (12) |
43 (11) |
<0.001 |
41 (11) |
43 (12) |
0.098 |
| 6-minute walk distance (m) |
402 (124) |
388 (114) |
0.125 |
339 (125) |
368 (107) |
0.006 |
| %predicted 6MWD |
77 (23) |
76 (22) |
0.480 |
66 (24) |
73 (21) |
0.002 |
| Blood oxygen saturation (%) |
95.0 (2.8) |
94.4 (2.7) |
0.012 |
93.9 (3.2) |
94.5 (2.7) |
0.031 |
| Emphysema LAA% (-950HU) |
16 (12) |
20 (13) |
<0.001 |
21 (13) |
19 (13) |
0.126 |
| mMRC Dyspnoea Score |
1.5 (1.0) |
1.7 (1.1) |
0.004 |
2.1 (1.0) |
1.8 (1.1) |
<0.001 |
| SGRQ Total Score |
41 (18) |
47 (19) |
<0.001 |
57 (16) |
50 (16) |
<0.001 |
| BODE Index |
2.5 (1.9) |
3.3 (2.0) |
<0.001 |
4.2 (2.2) |
3.4 (2.2) |
<0.001 |
| White blood cells (10^9/L) |
7.4 (2.0) |
7.5 (2.2) |
0.926 |
8.2 (2.5) |
7.9 (2.1) |
0.082 |
| Neutrophils, (10^9/L) |
4.8 (1.7) |
4.9 (2.1) |
0.601 |
5.6 (2.4) |
5.2 (1.9) |
0.084 |
| Platelets (10^9/L) |
261 (70) |
263 (69) |
0.713 |
281 (77) |
268 (70) |
0.055 |
| Fibrinogen (mg/dL) |
423 [376–490] |
438 [380–502] |
0.092 |
480 [416–543] |
444 [388–508] |
<0.001 |
| CRP (mg/dL) |
3.0 [1.4-6.5] |
3.4 [1.6-7.6] |
0.071 |
4.7 [2.1-10.4] |
3.1 [1.6-6.9] |
0.002 |
| SP-D (ng/mL) |
121 [86–167] |
125 [89–162] |
0.625 |
116 [85–162] |
114 [88–157] |
0.651 |
| PARC/CCL-18 (ng/mL) |
111 [86–141] |
110 [83–141] |
0.943 |
121 [94–162] |
113 [87–145] |
0.027 |
| PPPY COPD Hosp. Year 1 |
0.04 |
0.12 |
<0.001 |
0.65 |
0.38 |
0.004 |
| PPPY OCS only exbs Y1 |
0.04 |
0.05 |
0.218 |
0.38 |
0.29 |
0.218 |
| Diabetes |
11% |
6% |
0.024 |
8% |
9% |
0.689 |
| Cardiovascular (excluding HTN) |
33% |
33% |
0.904 |
29% |
37% |
0.072 |
| Reflux/heartburn |
23% |
23% |
0.890 |
32% |
33% |
0.888 |
| Anxiety |
13% |
20% |
0.003 |
24% |
16% |
0.022 |
| Depression symptoms | 20% | 29% | 0.004 | 36% | 28% | 0.058 |
P-values are comparisons between those who stayed in or changed exacerbation category. Data are mean (SD) or median [25% - 75% percentile].