Table 3.
Change in COPD patient characteristics between baseline and year 1 assessment
|
Year 1 Category |
Year 1 IE (n=1289) |
Year 1 FE (n=543) |
||||
|---|---|---|---|---|---|---|
|
Year 2 Category |
Stayed as IE (n=1068) |
Change to FE (n=221) |
p-value |
Stayed as FE (n=333) |
Change to IE (n=210) |
p-value |
| Change in patient measures (year 1 assessment – baseline) | ||||||
| BMI (kg/m2) |
0.0 (1.4) |
0.0 (1.1) |
0.750 |
-0.1 (1.4) |
-0.1 (1.6) |
0.589 |
| FEV1 (mL) |
14 (233) |
-46 (184) |
<0.001 |
-32 (180) |
-22 (217) |
0.543 |
| FEV1 % predicted |
0.4 (7.7) |
-1.6 (6.9) |
<0.001 |
-1.1 (6.4) |
-0.9 (7.8) |
0.690 |
| FEV1/FVC % |
-0.1 (5.8) |
-0.4 (5.2) |
0.534 |
-0.3 (6.0) |
-0.9 (6.0) |
0.250 |
| *Changed smoking status |
6% |
9% |
0.053 |
6% |
9% |
0.153 |
| *Re-Started smoking (%) |
5% |
9% |
0.051 |
4% |
4% |
0.726 |
| *Stopped smoking (%) |
7% |
10% |
0.448 |
9% |
17% |
0.125 |
| 6-min walk distance (m) |
10 (90) |
-5 (85) |
0.036 |
-6 (94) |
-1 (84) |
0.568 |
| Blood oxygen saturation (%) |
0.0 (2.9) |
-0.1 (3.0) |
0.478 |
-0.3 (3.3) |
-0.2 (2.8) |
0.713 |
| mMRC Dyspnoea Score |
0.0 (0.9) |
0.0 (1.0) |
0.682 |
0.1 (1.0) |
0.0 (1.0) |
0.691 |
| SGRQ Total Score |
--2.0 (10.6) |
--1.9 (12.1) |
0.879 |
-0.1 (9.9) |
-0.1 (10.2) |
0.986 |
| BODE Index |
0.0 (1.2) |
0.1 (1.3) |
0.138 |
0.2 (1.5) |
0.1 (1.3) |
0.424 |
| White blood cells (10^9/L) |
-0.3 (1.6) |
-0.2 (1.9) |
0.606 |
0.0 (2.3) |
-0.2 (2.1) |
0.289 |
| Neutrophils (10^9/L) |
-0.2 (1.5) |
-0.2 (1.9) |
0.894 |
0.2 (2.3) |
-0.1 (2.0) |
0.232 |
| Platelets (10^9/L) |
-7 (47) |
-11 (41) |
0.238 |
-5 (51) |
-16 (49) |
0.014 |
| Fibrinogen (mg/dL) |
-6 [-51, 36] |
0 [-38, 41] |
0.151 |
5 [-41,58] |
-3 [-52, 38] |
0.109 |
| CRP (mg/dL) |
0.1 [-1.3, 1.5] |
0.0 [-1.8, 2.1] |
0.999 |
0.3 [-1.4,3.0] |
-0.2 [-2.4, 1.9] |
0.083 |
| SP-D (ng/mL) |
0 [-18, 20] |
0 [-23, 26] |
0.654 |
-1 [-24, 24] |
0 [-21, 21] |
0.806 |
| PARC/CCL-18 (ng/mL) |
6 [-6, 21] |
6 [-9, 23] |
0.628 |
9 [-6, 27] |
6 [-7, 21] |
0.114 |
| Change between the number of events in year 1 and in year 2 | ||||||
| PPPY COPD Hosp. Year 2 |
0.07 |
0.57 |
<0.001 |
0.68 |
0.14 |
<0.001 |
| PPPY OCS only exbs Y2 | 0.04 | 0.25 | <0.001 | 0.37 | 0.06 | <0.001 |
P-values are comparisons between those who stayed in or changed exacerbation category. Mean (SD) or Median [25% - 75% percentile].
* - “Stopped smoking” are the current smokers at baseline who stopped before Year 1, “Re-started smoking” are the former smokers at baseline who started again before Year 1.