Figure 4. Significant deviation of qMRI tissue properties in an elderly subject and an MS patient.

Shown are a FLAIR (A) and T2-weighted image (B) of two axial slices of the head of an elderly subject (female, 72 years old, top two rows) and an MS patient (female, 40 years old, bottom two rows). The color overlay in C corresponds to the normalized difference ΔR₁/σ(R₁) between the subject and the group of healthy controls on the same slices. Only values higher than a threshold of 2.04are shown. Synthetic T2-weighted images are calculated using the R₁, R₂ and PD maps and used as background images. Similar for ΔR₂/σ(R₂) in D and ΔPD/σ(PD) in E. In F the magnitude of the normalized vector sum of ΔR₁/σ(R₁), ΔR₂/σ(R₂) and ΔPD/σ(PD) is shown where voxels that exceed a threshold of 5 are indicated in yellow.