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. 2013 May 24;98(8):E1314–E1322. doi: 10.1210/jc.2012-3937

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Copyright © 2013 by The Endocrine Society

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Figure 5. — Inhibition effect of compounds 4 and 15 on cell migration after 12 or 24 hours of treatment. A, Compounds 4 and 15 inhibited migration of BCPAP cells at 2.5 μM and 5.0 μM concentrations (*, P < .05 vs DMSO) after 12 hours of treatment, both compounds inhibited migration of TPC1 cells at 5 μM (*, P < .05 vs DMSO) after 24 hours of treatment, and neither compound significantly inhibited migration of FTC133 cells at either 2.5 μM or 5.0 μM concentrations after 12 hours of treatment. B, Transfection of BCPAP cells with a constitutively activated PAK1 cDNA rescues the inhibition of migration of compounds 4, 15, and OSU-03012 (*, P < .05; **, P < .01). Rescue experiments for each compound were performed on 3 separate occasions.