Table 1.
Potencies of Compounds for Reducing Viability of BCPAP, FTC133, and TPC1 Cells Versus DMSO Controla
| Compound | IC50, μmol/L |
||
|---|---|---|---|
| BCPAP | FTC133 | TPC1 | |
| OSU-03012 | 2.93 ± 1.05 | 2.93 ± 1.87 | 2.80 ± 1.33 |
| 1 | 2.01 ± 0.59 | 4.78 ± 4.53 | 2.60 ± 0.81 |
| 2 | 2.67 ± 0.82 | 4.83 ± 4.47 | 1.81 ± 1.24 |
| 3 | 2.34 ± 0.27 | 5.32 ± 4.05 | 3.17 ± 1.29 |
| 4 | 2.07 ± 0.06 | 2.68 ± 2.08 | 1.68 ± 0.32 |
| 5 | >10 | 5.03 ± 0.25 | >10 |
| 6 | >10 | >10 | >10 |
| 7 | 3.71 ± 1.82 | 4.53 ± 2.57 | 3.67 ± 1.52 |
| 8 | 2.90 ± 2.35 | 3.08 ± 1.63 | 4.67 ± 4.16 |
| 9 | 4.04 ± 1.38 | 4.75 ± 2.47 | 2.42 ± 0.13 |
| 10 | 6.53 ± 2.16 | 8.95 ± 0.57 | 7.39 ± 1.90 |
| 11 | 4.50 ± 1.04 | 3.94 ± 2.29 | 4.98 ± 1.94 |
| 12 | 3.76 ± 1.20 | 7.55 ± 2.19 | 5.83 ± 1.73 |
| 13 | 2.76 ± 1.56 | 4.95 ± 3.21 | 3.62 ± 0.42 |
| 14 | 3.32 ± 1.09 | 5.42 ± 1.56 | 5.98 ± 0.28 |
| 15 | 1.49 ± 0.68 | 3.37 ± 3.31 | 2.66 ± 1.05 |
| 16 | >10 | >10 | 4.38 ± 2.18 |
| 17 | >10 | >10 | 8.96 ± 1.17 |
a
The reported IC50 values are concentrations at which BCPAP, FTC133, and TPC1 cell viability by MTT assays are 50% of DMSO control after 72 hours of exposure. Data are presented as mean ± SD (n = 3).