Table 3. The top 10 amino acids enriched and depleted around known phosphorylation sites as determined by Fisher’s permutation test (29).
| Enriched | Depleted | ||||
|---|---|---|---|---|---|
| Position | Residue | P-value | Position | Residue | P-value |
| Serine sites | |||||
| –3 |
R |
<0.0001 |
–11 |
L |
<0.0001 |
| –2 |
R |
<0.0001 |
–5 |
C |
<0.0001 |
| +1 |
P |
<0.0001 |
–3 |
C |
0.0002 |
| +2 |
E |
<0.0001 |
+2 |
L |
0.0002 |
| +3 |
E |
<0.0001 |
+2 |
N |
0.0002 |
| +4 |
S |
<0.0001 |
+3 |
L |
0.0002 |
| –6 |
K |
0.0001 |
–6 |
L |
0.0003 |
| –5 |
R |
0.0001 |
–3 |
F |
0.0003 |
| –4 |
S |
0.0001 |
–2 |
N |
0.0003 |
| +2 |
S |
0.0001 |
–4 |
V |
0.0004 |
| Threonine sites | |||||
| –3 |
R |
<0.0001 |
–4 |
L |
0.0019 |
| –2 |
R |
<0.0001 |
+7 |
L |
0.0032 |
| +1 |
P |
<0.0001 |
+1 |
N |
0.0063 |
| –12 |
K |
0.0001 |
–2 |
N |
0.0064 |
| +12 |
E |
0.0006 |
+1 |
F |
0.0106 |
| +2 |
R |
0.0007 |
–3 |
L |
0.0141 |
| –9 |
S |
0.0015 |
+4 |
I |
0.0152 |
| +2 |
D |
0.0028 |
+2 |
L |
0.0162 |
| +6 |
K |
0.0054 |
+1 |
A |
0.0165 |
| –6 |
G |
0.0060 |
–4 |
A |
0.0178 |
| Tyrosine sites | |||||
| –4 |
E |
<0.0001 |
–4 |
L |
0.0001 |
| –1 |
E |
<0.0001 |
+2 |
L |
0.0005 |
| +3 |
M |
<0.0001 |
–4 |
I |
0.0009 |
| +5 |
P |
<0.0001 |
+8 |
I |
0.0009 |
| +9 |
P |
<0.0001 |
+6 |
F |
0.0019 |
| –3 |
E |
0.0001 |
–3 |
L |
0.0021 |
| +2 |
N |
0.0001 |
–2 |
L |
0.0023 |
| –2 |
P |
0.0003 |
–10 |
N |
0.0045 |
| –7 |
S |
0.0004 |
+11 |
I |
0.0054 |
| –3 | N | 0.0007 | –10 | V | 0.0065 |