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. 2013 Aug 5;8(8):e72004. doi: 10.1371/journal.pone.0072004

Figure 2. Effect of NPR-C blockade on musclin-induced vasoconstriction.

Figure 2

Inhibitory effect of the antibody (ab14355) specific to NPR-C on vasoconstriction induced by musclin (0.01 nmol/L) in aorta strips isolated from spontaneously hypertensive rats (SHR). In the presence of the indicated concentration of ab14355, the responses to musclin were evaluated. Vasoconstriction induced by musclin was expressed as the percentage of contraction induced by potassium chloride (50 mmol/L). Data represent the mean ± SEM of 8 animals. *Significance as compared with the vehicle-treated control (without ab14355) using one-way ANOVA with Dunnett’s test compared against no antibody.