Figure 4.
Immunostain for matrix metalloproteinase-2 (MMP-2; a) and tissue inhibitor of metalloproteinase-2 (TIMP-2; b) antibodies (DAB, X200) of infected control liver sections of mice sacrificed at the 10th week post infection showing moderate and mild positively stained hepatocytes and granuloma (fibroblast and inflammatory cells; arrows), respectively. Sections taken from livers of mice treated with PZQ (500 mg/kg/day, p.o., for 2 consecutive days) showing moderate (a) and mild (b) positively stained hepatocytes, and granuloma cells (arrows). Sections taken from livers of mice treated with telmisartan (10 mg/kg/day, p.o., for 5 weeks) showing moderate (a) and mild (b) positively stained hepatocytes, and granuloma cells (arrows). Sections taken from livers of mice treated with PZQ combined with telmisartan showing moderate (a) and mild (b) positively stained hepatocytes and granuloma cells (arrows).