Table 3. Distribution of the neisserial DUS in CDS of N.meningitidis Z2491 by COG groupa.
| COG groups | No. of DUS | No. of CDS | Average CDS length | Relative abundance (95% CI) | |
|---|---|---|---|---|---|
| All |
|
653 |
2065 |
854 |
22.0 (20.4-23.8) |
| C |
Energy production, conversion |
23 |
104 |
1111 |
11.8 (7.5-17.7) |
| D |
Cell division, chromosome partitioning |
14 |
24 |
1129 |
30.7 (16.8-51.5) |
| E |
Amino acid transport, metabolism |
69 |
137 |
1141 |
26.2 (20.4-33.1) |
| F |
Nucleotide transport, metabolism |
13 |
48 |
1005 |
16.0 (8.5-27.4) |
| G |
Carbohydrate transport, metabolism |
14 |
56 |
1093 |
13.6 (7.4-22.8) |
| H |
Coenzyme metabolism |
39 |
74 |
939 |
33.4 (23.7-45.6) |
| I |
Lipid metabolism |
10 |
40 |
930 |
16.0 (7.7-29.4) |
| J |
Translation, ribosomal structure and biogenesis |
53 |
142 |
830 |
26.8 (20.1-35.0) |
| K |
Transcription |
15 |
61 |
875 |
16.7 (9.4-27.6) |
| L |
DNA replication, recombination, repair |
98 |
163 |
1087 |
32.8 (26.7-40.0) |
| GMG |
Genome maintenance genes |
97 |
95 |
1369 |
44.2 (35.9-53.9) |
| L- |
Others: mostly transposases |
1 |
68 |
693 |
1.3 (0.03-7.1) |
| M |
Cell envelope biogenesis, outer membrane |
61 |
123 |
1178 |
25.0 (19.1-32.1) |
| N |
Cell motility and secretion |
6 |
49 |
985 |
7.4 (2.7-16.1) |
| O |
Posttranslational modification, protein turnover, chaperones |
17 |
66 |
1031 |
14.8 (8.7-23.8) |
| P |
Inorganic ion transport, metabolism |
22 |
74 |
1200 |
14.7 (9.2-22.3) |
| Q |
Secondary metabolites biosynthesis, transport and catabolism |
8 |
27 |
1133 |
15.5 (6.7-30.6) |
| R |
General function prediction only |
60 |
148 |
906 |
26.6 (20.3-34.3) |
| S |
Function unknown |
37 |
147 |
684 |
22.0 (15.5-30.3) |
| T |
Signal transduction mechanisms |
7 |
27 |
966 |
16.0 (6.4-32.9) |
| nab | Unclassified | 87 | 555 | 467 | 20.1 (16.1-24.8) |
aGMG were defined as genes involved in DNA replication, recombination, repair and restriction/modification and made into a separate group; otherwise, the COG classification was used. The number of DUS per group was counted. DUS frequencies are reported by their relative abundance: the number of DUS found divided by the expected number of DUS as estimated by a fourth order Markov model. We find 95% confidence intervals for the number of DUS assuming a Poisson distribution, and divide by the expected number of DUS as for the relative abundance.
bNot applicable.