Table 1.
Experimental groups, mortality rates, survival times and fever responses of the 46 rabbits subjected to RHDV challenge following previous RCV-A1 exposure
| ID | Sex | Inoculation | Survival | Survival time [d] | Adjusted survival time [d]* | Fever** | Duration of fever [h] *** |
|---|---|---|---|---|---|---|---|
|
Group 1 |
|
|
|
|
|
|
|
|
< 8 weeks between RCV-A1 and RHDV infection |
|
|
|
||||
|
18 |
m |
infected |
Y |
|
|
Y |
|
|
11 |
f |
contact |
Y |
|
|
N |
|
|
40 |
f |
contact |
Y |
|
|
Y |
|
| 7 |
m |
infected |
N |
8.8 |
|
Y |
41.0 |
| 29 |
m |
infected |
N |
9.9 |
|
Y |
5.0 |
| 31 |
f |
infected |
N |
2.6 |
|
N |
|
| 37 |
m |
infected |
N |
11.4 |
|
Y |
15.0 |
| 36 |
m |
contact |
N |
12.2 |
9.8 |
Y |
13.0 |
|
Group 2 |
|
|
|
|
|
|
|
|
8-10 weeks between RCV-A1 and RHDV infection |
|
|
|
||||
|
25 |
f |
contact |
Y |
|
|
Y |
|
| 20 |
F |
infected |
N |
10.5 |
|
Y |
14.0 |
| 38 |
m |
infected |
N |
8.5 |
|
N |
|
| 50 |
f |
infected |
N |
4.5 |
|
Y |
14.5 |
| 28 |
m |
contact |
N |
10.4 |
8.0 |
Y |
15.0 |
| 39 |
m |
contact |
N |
12.2 |
9.8 |
Y |
4.5 |
| 44 |
f |
contact |
N |
9.9 |
7.5 |
Y |
15.0 |
| 47 |
f |
contact |
N |
7.0 |
4.6 |
Y |
22.0 |
|
Group 3 |
|
|
|
|
|
|
|
|
>10 weeks between RCV-A1 and RHDV infection |
|
|
|
||||
|
32 |
f |
infected |
Y |
|
|
Y |
|
| 2 |
f |
infected |
N |
4.5 |
|
Y |
14.5 |
| 3 |
f |
infected |
N |
3.4 |
|
Y |
2.3 |
| 4 |
f |
infected |
N |
2.6 |
|
Y |
7.5 |
| 6 |
m |
infected |
N |
7.4 |
|
Y |
16.0 |
| 12 |
f |
infected |
N |
4.4 |
|
Y |
5.3 |
| 15 |
f |
infected |
N |
4.6 |
|
Y |
15.8 |
| 16 |
m |
infected |
N |
7.3 |
|
Y |
14.0 |
| 17 |
m |
infected |
N |
8.3 |
|
Y |
6.5 |
| 19 |
m |
infected |
N |
3.2 |
|
Y |
3.5 |
| 21 |
f |
infected |
N |
2.5 |
|
Y |
14.0 |
| 24 |
f |
infected |
N |
2.2 |
|
N |
|
| 8 |
m |
contact |
N |
7.0 |
4.6 |
Y |
5.0 |
| 23 |
f |
contact |
N |
6.1 |
3.7 |
Y |
4.5 |
| 26 |
m |
contact |
N |
6.2 |
3.8 |
Y |
9.0 |
| 27 |
m |
contact |
N |
9.3 |
6.9 |
Y |
12.0 |
| 33 |
f |
contact |
N |
11.0 |
8.6 |
N |
|
| 45 |
f |
contact |
N |
4.2 |
1.8 |
Y |
6.5 |
|
Rabbits with unknown infection history |
|
|
|
||||
|
30 |
f |
infected |
Y |
|
|
N |
|
| 10 |
f |
infected |
N |
6.2 |
|
Y |
6.5 |
| 14 |
f |
infected |
N |
2.8 |
|
Y |
11.5 |
| 35 |
f |
infected |
N |
9.5 |
|
Y |
32.0 |
| 48 |
f |
infected |
N |
9.7 |
|
Y |
11.0 |
| 49 |
f |
infected |
N |
4.0 |
|
Y |
3.0 |
| 1 |
f |
contact |
N |
7.8 |
5.4 |
Y |
12.0 |
| 5 |
f |
contact |
N |
7.7 |
5.3 |
Y |
9.5 |
| 34 |
f |
contact |
N |
15.8 |
13.4 |
N |
|
| 42 |
f |
contact |
N |
6.7 |
4.3 |
Y |
9.5 |
| 43 |
f |
contact |
N |
4.7 |
2.3 |
N |
|
| 46 | f | contact | N | 5.2 | 2.8 | Y | 5.0 |
Surviving animals are shown in bold italics.
*Adjusted survival time is −2.4 days for the contact infected animals.
** Temperature >40.5°C. *** Time between recorded onset of fever and death.