Table 3. IPA Analysis: Toxicological Cellular Pathways Significantly Represented by HIF2α Regulation in RCC.
| Top Toxicological Pathways and Functions Differentially Associated with VHL-mut and VHL-wt RCC Cell Lines | ||
| Toxicological Pathways | P-value | |
| Mitochondrial Dysfunction | 7.75E-04 | |
| Hypoxia-Inducible Factor Signaling | 1.24E-03 | |
| Aryl Hydrocarbon Receptor Signaling | 9.66E-03 | |
| Oxidative Stress | 1.25E-02 | |
| Decreases Permeability Transition of Mitochondria and Mitochondrial Membrane | 1.51E-02 | |
a
Symbol abbreviations are gene.