Table 1. Genome-wide significant epistatic pairs identified in the ARIC cohort and their replication in the NFBC199 cohort.^* .

Trait	SNP1	chr1	pos1	gene1	SNP2	chr2	pos2	gene2	Pint	rep_SNP1	rep_SNP2	rep_ Pint
SBP	rs409354	11	16 876 618	PLEKHA7	rs1417733	13	95 327 273	near GPR180	4.3E-13	rs10832696	rs942149	7.2E-03
TRI	rs10892020	11	116 589 652	near BUD13	rs17119975	11	116 634 557	BUD13	6.5E-16	rs7123583	rs2075295	2.1E-04
TRI	rs3741298a	11	116 657 561	ZNF259	rs7396835	11	116 684 028	near APOA4	1.0E-09	rs7123583	rs2075295	2.1E-04
TRI	rs3741298a	11	116 657 561	ZNF259	rs7396851	11	116 684 164	near APOA4	1.8E-09	rs7123583	rs2075295	2.1E-04
TRI	rs12799766a	11	116 558 427	near BUD13	rs10892020	11	116 589 652	near BUD13	6.0E-09b	rs7123583	rs2075295	2.1E-04
HDL	rs1285884	6	7 143 075	RREB1	rs247617a	16	56 990 716	near CETP	2.8E-08b	rs11755724	rs7499892	3.5E-02

^*: genome-wide significant thresholds for interactions involving marginal SNPs were 2.1E-09 for TRI and 3.5E-09 for HDL; SNP₁ (SNP₂), chr₁ (chr₂), pos₁ (pos₂), gene₁ (gene₂) – name, chromosome, position and mapped gene of the first (second) SNP; P_int – P value of the interaction test; rep_SNP₁ (rep_SNP₂, rep_P_int) – the first (second, interaction P value) SNP of the best replicated pair;

^a: the genome-wide significant single SNP with marginal effects;

^b: genome-wide suggestive.