Table 2. Local interactions captured additional genome-wide significant loci identified in GWAS of the eight traits in ARIC and/or NFBC1966.^* .

Region	gene	Trait	SNP1	pos1	SNP2	pos2	Pint	LD (r2)	rep_SNP1	rep_SNP2	rep_ Pint
2p24.1	APOB	LDL	rs427021	21451458	rs386397	21451827	9.5E-10	0.26	rs10206521	rs312046	1.9E-03
5q13.3	HMGCR	LDL	rs2006760	74562029	rs1559203	75449814	7.0E-06	0	rs6866661	rs10072459	1.1E-02
8p21.3	LPL	HDL	rs1441766	19862788	rs7461115	19871540	9.7E-07	0.22	rs894210	rs2410630	1.1E-02
8p21.3	LPL	TRIb	rs1441766	19862788	rs7013777	19878356	1.2E-06	0.23	rs10099160	rs10103634	1.0E-03
11q21-q14.3	MTNR1B	GLU	rs10765558	92493781	rs56247942	92999977	5.7E-06	0	rs505423	rs1374475	3.3E-03
11q23.3	ZNF259,APOA5	HDL	rs3741298	116657561	rs7396835	116684028	1.8E-07	0.05	Nil	Nil	Nil
12q24.31	near HNF1A a	CRP	rs2708104	121483949	rs1718161	121627458	1.5E-06	0.00	rs11065408	rs2230912	3.4E-02
16q13	CETP	HDL	rs9989419c	56985139	rs12708980	57012379	5.6E-06	0.00	rs7499892	rs4784744	1.2E-02
16q13-q21	CETP a	HDL	rs9989419c	56985139	rs4783999	57651985	6.7E-06	0.03	rs2518054	rs12708990	4.5E-04
19p13.2	LDLR	LDL	rs12052058c	11159525	rs1799898	11227554	1.8E-06	0.10	rs11668477	rs2228671	2.6E-04
19q13.32	TOMM40, APOE	LDL	rs4803750c	45247627	rs4803759	45327459	4.4E-06	0.02	rs4803750	rs4803760	3.4E-04

^*: SNP₁ (SNP₂), pos₁ (pos₂) – name and position the first (second) SNP; P_int – P value of the interaction test; rep_SNP₁ (rep_SNP₂, rep_P_int) – the first (second, interaction P value) SNP of the best replicated pair; LD: r² linkage disequilibrium between two epistatic SNPs.

^a: detected in NFBC1966 and test replication in ARIC;

^b: region shared in multiple traits;

^c: genome-wide significant marginal SNP.