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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: ChemMedChem. 2012 Oct 11;7(12):2093–2100. doi: 10.1002/cmdc.201200352

Scheme 1.

Scheme 1

Synthesis of 2a-2h: Reagents and conditions: (a) RCHO, NaCNBH3, AcOH, 1,2-dichloroethane, rt, overnight (for compounds 2a-2f), (b) 4-(bromomethyl)benzenesulfonamide, K2CO3, DMT, rt, overnight (for compound 2g) (c) p-Toluenesulfonyl chloride, Et3N, DCM, rt, overnight (for compound 2h)