Scheme 2.
Synthesis of 4a-4f: Reagents and conditions: (a) RCHO, NaCNBH3, AcOH, 1,2-dichloroethane, rt, overnight (for compounds 4a-4e), (b) 4-(bromomethyl)benzenesulfonamide, K2CO3, DMT, rt, overnight (for compound 4f).
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