. 2013 Aug 5;8(8):e70694. doi: 10.1371/journal.pone.0070694

Table 1. Allelic frequencies and associations with perioperative fentanyl use of SNPs in 13 LD blocks in the CACNA1E gene.

LDnumber	SNP name	Major:Minorallele	Allelicfrequency	p- value	LDnumber	SNP name	Major:Minorallele	Allelicfrequency	p- value
1	rs633143^*	G:A	0.100	0.433	6	rs3766988	A:G	0.015	–
	rs2877651^*	G:A	0.090	0.491		rs7513540	G:T	0.205	–
	rs556321	A:G	0.187	–		rs3845444	T:G	0.205	–
	rs553042^*	T:C	0.365	0.646		rs4306091	A:G	0.015	–
	rs12060765	G:T	0.090	–		rs7540850	C:T	0.235	–
	rs943795	T:C	0.365	–		rs2253388	C:T	0.235	–
2	rs576006	A:G	0.309	–		rs4651112	G:A	0.195	–
	rs12405860^*	A:G	0.190	0.662	7	rs12139677^*	T:G	0.370	0.402
	rs558994^*	G:A	0.295	0.882		rs3845445	T:C	0.045	–
	rs17494681^*	C:T	0.110	0.087		rs2280866^*	G:A	0.305	0.522
	rs681271^*	C:T	0.485	0.927	8	rs3767002^*	C:T	0.180	0.399
	rs4126690^*	C:A	0.165	0.435		rs16858051	T:C	0.015	–
	rs517209^*	C:A	0.460	0.468		rs3753748^*	G:A	0.195	0.609
3	rs589082	C:A	0.485	–		rs3767003^*	A:G	0.240	0.957
	rs10910948^*	T:C	0.120	0.218	9	rs3767004^*	G:A	0.275	0.867
	rs16857509	A:G	0.010	–		rs704332^*	T:C	0.240	0.957
	rs625226^*	A:G	0.125	0.440		rs704331^*	A:G	0.390	0.626
	rs4146634^*	A:G	0.485	0.783		rs4652678^*	T:C	0.060	0.112
	rs2225875^*	C:T	0.205	0.103		rs704329^*	G:A	0.455	0.990
	rs6681017	C:T	0.120	–		rs4652679	G:A	0.060	–
	rs1933049	G:A	0.480	–		rs697260	G:A	0.175	–
	rs12024842	A:G	0.270	–		rs199922	A:G	0.045	–
	rs4652663	T:C	0.120	–		rs199923	G:A	0.060	–
	rs11580052	G:A	0.485	–		rs199930	C:T	0.060	–
	rs7524309	A:G	0.215	–		rs2280868^*	C:A	0.185	0.796
	rs10797724	G:A	0.270	–	10	rs473200^*	C:T	0.265	0.638
4	rs10797729^*	G:A	0.265	0.287		rs601059	C:T	0.270	–
	rs10797730^*	C:T	0.295	0.077		rs704326^*	C:T	0.450	0.296
	rs1999838	A:G	0.295	–	11	rs3845446^*	A:G	0.335	0.032
	rs7511748	T:G	0.270	–		rs3753752	C:T	0.335	–
	rs12135959	G:A	0.300	–		rs2280869	T:C	0.335	–
	rs3856090	C:T	0.295	–	12	rs12045458^*	A:G	0.105	0.727
	rs10494540	G:T	0.300	–		rs7513685^*	G:A	0.095	0.177
	rs10494541	G:A	0.005	–		rs610100^*	C:A	0.490	0.341
	rs12138634	G:T	0.300	–		rs480752^*	C:A	0.055	0.192
	rs12239392	G:A	0.030	–		rs12130868^*	C:T	0.400	0.422
	rs2877652	T:C	0.030	–		rs1281194	A:G	0.480	–
	rs6684423	T:G	0.031	–		rs12136390	C:T	0.395	–
	rs3856094^*	G:A	0.250	0.246		rs585315^*	C:T	0.395	0.601
5	rs199943^*	A:C	0.050	0.244		rs12071191	G:A	0.285	–
	rs12071300	T:G	0.050	–		rs486003	G:A	0.395	–
6	rs199916^*	G:A	0.190	0.794		rs695072	T:C	0.085	–
	rs3820260	C:T	0.040	–		rs13375273	G:A	0.490	–
	rs3766980^*	C:T	0.245	0.886		rs4465155	C:T	0.425	–
	rs3753737^*	A:G	0.205	0.969		rs7533297	T:C	0.405	–
	rs10910979	C:T	0.245	–		rs7535666	T:G	0.110	–
	rs3845441	T:C	0.190	–	13	rs598714^*	A:C	0.480	0.983
	rs4652673	A:G	0.205	–		rs677618^*	T:C	0.375	0.581

Tag SNPs in the LD blocks (selected using Tagger software with default settings; r²>0.8). p-value, association with perioperative fentanyl use (Kruskal-Wallis test).