Table 2. Selected genes overexpressed in schistosomes from water buffalo compared to those from goats.a .
| Pathway | Probe name | Accession | Gene and/or protein homology | Fold change | p value | FDR |
| Lipid Metabolism | Glycerophospholipid metabolism | |||||
| CUST_3764 | CNUS0000098059 | Prostaglandin synthase 1 | 2.19 | 0.021 | 0.007 | |
| CUST_7726 | CNUS0000102024 | Acetylcholinesterase 1 | 2.71 | 0.036 | 0.007 | |
| Glycerophospholipid metabolism & Glycerolipid metabolism | ||||||
| CUST_8880 | CNUS0000103178 | Acyltransferase-like family member 8 | 2.57 | 0.026 | 0.008 | |
| Sphingolipid metabolism | ||||||
| CUST_6882 | CNUS0000101178 | Degenerative spermatocyte homolog 1 | 2.45 | 0.021 | 0.008 | |
| genetic information processing | Purine metabolism, Pyrimidine metabolism | |||||
| CUST_3246 | CNUS0000097541 | DNA primase small subunit | 2.02 | 0.023 | 0.01 | |
| CUST_9849 | CNUS0000104147 | Nucleoside-diphosphate kinase | 2.08 | 0.001 | 0 | |
| Transcription | ||||||
| CUST_9094 | CNUS0000103392 | Transcription initiation factor TFIIE alpha | 2.34 | 0.018 | 0.008 | |
| Spliceosome | ||||||
| CUST_11072 | CNUS0000105370 | Hypothetical protein | 2.62 | 0.036 | 0.01 | |
| CUST_488 | FN317168 | SJFCE0697 | 3.69 | 0.022 | 0.008 | |
| CUST_7382 | CNUS0000101679 | Expressed protein | 4.53 | 0.019 | 0.007 | |
| Translation | ||||||
| CUST_6052 | CNUS0000100348 | Small subunit ribosomal protein S27Ae | 4.71 | 0.002 | 0.007 | |
| Folding, Sorting and Degradation | Proteasome | |||||
| CUST_3409 | CNUS0000097704 | 26S proteasome regulatory subunit N12 | 3.26 | 0.001 | 0.006 | |
| Ubiquitin mediated proteolysis | ||||||
| CUST_9175 | CNUS0000103473 | Bromodomain and WD repeat domain containing 3 | 2.55 | 0.001 | 0.006 | |
| RNA degradation | ||||||
| CUST_2890 | CNUS0000097185 | RNA-binding protein Rrp4 and related proteins | 6.13 | 0.020 | 0.007 | |
a
This list includes the probe name, gene accession number, fold change, as well as p- and q-values for protein homology (BlastX). In the gene accession columns, data with identifiers such as CNUS0000098407 were retrieved from the S. japonicum genome project database (LSBI; http://lifecenter.sgst.cn/schistosoma/cn/genomeProject.do; in Japanese) and those with identifiers FN326902 were retrieved from The European Molecular Biology Laboratory database (http://www.ebi.ac.uk/ena/). The FDR (q-value) was determined using the false discovery rate as a control using R statistical language (http://www.bioconductor.org/packages/release/bioc/html/qvalue.html).