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. 2013 Aug 5;8(8):e70367. doi: 10.1371/journal.pone.0070367

Table 3. Selected downregulated genes in schistosomes from water buffalo compared with those from goats.a .

Pathway Probe name Accession Gene and/or protein homology Fold change p value FDR
Signal transtruction MAPK signaling pathway
CUST_11642 CNUS000010594 Akt1;RAC serine/threonine-protein kinase −6.92 0.022 0.005
CUST_12915 CNUS0000107219 Protein RSKN-1 −2.48 0.018 0.005
CUST_3675 CNUS0000097970 MAPK/ERK kinase 1(MEK-1) −4.15 0.0002 0
CUST_9010 CNUS0000103308 MAPK/ERK kinase 6(MEK-6) −2.91 0.003 0
CUST_9047 CNUS0000103345 Protein KIN-18 −15.09 0.0003 0
CUST_3717 CNUS0000098012 Epidermal growth factor receptor −4.52 0.004 0.005
CUST_9487 CNUS0000103785 Probable beta-arrestin −2.33 0.040 0.007
CUST_5301 CNUS0000099597 Heat shock 70 kDa protein cognate 4 −2.24 0.024 0.01
ErbB signaling pathway
CUST_11642 CNUS0000105941 Akt1;RAC serine/threonine-protein kinase −6.92 0.022 0.005
CUST_3675 CNUS0000097970 MAPK/ERK kinase 1 −4.15 0.0002 0
CUST_5301 CNUS0000099597 Heat shock 70 kDa protein cognate 4 −2.24 0.024 0.01
Wnt signaling pathway, Notch signaling pathway
CUST_5485 CNUS0000099781 Dishevelled protein(Dsh) −4.48 0.001 0.005
Endocrine System Progesterone-mediated oocyte maturation
CUST_11642 CNUS0000105941 Akt1;RAC serine/threonine-protein kinase −6.92 0.022 0.005
CUST_12915 CNUS0000107219 Protein RSKN-1 −2.48 0.018 0.005
CUST_3675 CNUS0000097970 MAPK/ERK kinase 1 −4.15 0.0002 0
Development/Reproduction Dorso-ventral axis formation
CUST_3675 CNUS0000097970 MAPK/ERK kinase 1 −4.15 0.0002 0
CUST_3717 CNUS0000098012 Epidermal growth factor receptor −4.52 0.004 0.005
Reproduction
CUST_12936 CNUS0000107240 Prostatic spermine-binding protein (SBP) −7.27 0.012 0.005
Immune System Natural killer cell mediated cytotoxicity
CUST_3675 CNUS0000097970 MAPK/ERK kinase 1 −4.15 0.0002 0
Endocytosis CUST_10516 CNUS0000104814 beta-adrenergic-receptor kinase −2.05 0.0033 0
CUST_3717 CNUS0000098012 Epidermal growth factor receptor −4.52 0.004 0.005
CUST_5301 CNUS0000099597 Heat shock 70 kDa protein cognate 4 −2.24 0.024 0.01
CUST_8672 CNUS0000102970 Partitioning-defective 3 homolog (PAR-3) −3.85 0.032 0.005
CUST_9487 CNUS0000103785 Probable beta-arrestin −2.33 0.040 0.007
Amino Acid Metabolism CUST_4493 CNUS0000098788 Aspartate aminotransferase −2.11 0.001 0.005
CUST_6397 CNUS0000100693 Dopamine beta-hydroxylase −3.02 0.037 0.012
CUST_6212 CNUS0000100508 Aromatic-L-amino-acid decarboxylase −4.70 0.029 0.01
Carbohydrate Metabolism Inositol phosphate metabolism
CUST_10542 CNUS0000104840 Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha (PI3K-C2α) −2.43 0.025 0.008
CUST_13086 CNUS0000107391 Phosphatidylinositol 4-kinase alpha (PI4Kα) −2.03 0.027 0.01
Citrate cycle (TCA cycle),Pyruvate metabolism
CUST_6418 CNUS0000100714 Pyruvate carboxylase −2.61 0.002 0.005
Galactose metabolism, Amino sugar and nucleotide sugar metabolism
CUST_7443 CNUS0000101740 Galactokinase 2(GALK2) −3.99 0.019 0.008
Glycan Biosynthesis and Metabolism Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
CUST_7658 CNUS0000101956 Glycosylphosphatidylinositol anchor attachment protein 1(GPAA1) −3.07 0.0016 0.005
N-Glycan biosynthesis
CUST_9370 CNUS0000103668 Glycoprotein(Protein GLY-2) −2.00 0.007 0.006