Table 1. Five published MAPK pathways examined for enrichment with AAMD-associated genomic intervals.

		Genes			Enrichment	P-value
Pathway	Source	In Pathway	Tested	AMD-Associated	Empirical	Adjusted
MAPK *	BioCartaa	86	49	9	0.014	0.037
MAPK *	KEGGb	261	144	19	0.153	0.339
JNK MAPK	STKEc	38	25	6	0.002	0.006
p38 MAPK	STKE	35	23	5	0.021	0.057
p38 MAPK	BioCarta	39	21	5	0.023	0.070

Note: AAMD, advanced age-related macular degeneration;

^ainformation on BioCarta pathways exists at: http://www.biocarta.com;

^binformation on KEGG pathways exists at: http://www.genome.jp/kegg/pathway (MAPK: hsa04010);

^cinformation on STKE pathways exists at: http://stke.sciencemag.org (JNK MAPK: CMP_10827; p38 MAPK: CMP_10958).

^*‘MAPK’ pathways from BioCarta and KEGG include constituents of the 4 major MAPK cascades (JNK MAPK, p38 MAPK, ERK1/ERK2, ERK5). Empirical P-values for pathway interval enrichment were obtained from permutation test applying 100,000 iterations. Enrichment P-values were adjusted for multiple testing, as described in the Methods section.