Table 1.
Differential expressed proteins identified by MALDI-TOF-MS between serum of HBV hepatic fibrosis and HBV carriers
| Spot | Accession number | Protein name | Mass weight | pI | Sequence coverage (%) | Scores | Ratio* | Function |
|---|---|---|---|---|---|---|---|---|
| 1 |
P02771 |
Alpha-fetoprotein |
69500 |
5.31 |
19 |
203 |
↑2.01 |
biomarker |
| 2 |
P08833 |
Insulin-like growth factor-binding protein 1 |
33200 |
4.9 |
23 |
262 |
↑2.01 |
Cell growth |
| 3 |
P02741 |
C-reactive protein |
23760 |
5.12 |
23 |
570 |
↑2.02 |
calcium binding |
| 4 |
P19838 |
Nuclear factor NF-kappa-B p105 subunit |
105356 |
6.09 |
18 |
186 |
↑2.02 |
DNA binding |
| 5 |
P2671 |
Fibrinogen alpha chain |
66818 |
7.65 |
8 |
298 |
↑2.03 |
receptor binding |
| 6 |
Q03135 |
Caveolin-1 |
20472 |
6.95 |
9 |
78 |
↑2.03 |
enzyme activity |
| 7 |
P05121 |
Plasminogen activator inhibitor 1 |
48577 |
6.77 |
12 |
138 |
↑2.11 |
blood coagulation |
| 8 |
P00505 |
Aspartate aminotransferase |
47476 |
4.87 |
19 |
110 |
↑2.26 |
catalytic activity |
| 9 |
P01137 |
Transforming growth factor beta-1 |
40412 |
5.86 |
12 |
188 |
↑2.29 |
Cell growth |
| 10 |
P04271 |
Protein S100-B |
10713 |
4.43 |
8 |
154 |
↑2.31 |
calcium binding |
| 11 |
P24298 |
Alanine aminotransferase 1 |
54637 |
5.11 |
13 |
908 |
↑2.89 |
catalytic activity |
| 12 |
Q14116 |
Interleukin-18 |
21326 |
5.23 |
27 |
392 |
↑2.97 |
signal transducer |
| 13 |
P01375 |
Tumor necrosis factor |
25644 |
5.43 |
18 |
152 |
↑3.01 |
apoptotic process |
| 14 |
P08253 |
Matrix metallopeptidase 2 |
73882 |
6.57 |
30 |
150 |
↑3.01 |
metastasis |
| 15 |
P01579 |
Interferon gamma |
19348 |
5.67 |
16 |
335 |
↑3.21 |
receptor binding |
| 16 |
P01034 |
Cystatin-C |
13120 |
7.11 |
13 |
262 |
↑3.57 |
enzyme activity |
| 17 |
P05187 |
Alkaline phosphatase |
57954 |
6.14 |
16 |
362 |
↑3.66 |
hydrolase activity, |
| 18 |
P01033 |
Metalloproteinase inhibitor 1 |
23171 |
5.28 |
4 |
74 |
↑4.21 |
metastasis |
| 19 |
P07996 |
Thrombospondin-1 |
25695 |
6.67 |
6 |
166 |
↑7.56 |
blood coagulation |
| 20 |
P17936 |
Insulin-like growth factor-binding protein 3 |
31674 |
5.03 |
8 |
304 |
↓2.17 |
Cell growth |
| 21 |
P37231 |
Peroxisome proliferator-activated receptor gamma |
57620 |
5.23 |
25 |
946 |
↓2.72 |
DNA binding |
| 22 |
P04180 |
Phosphatidylcholine-sterol acyltransferase |
49578 |
5.68 |
17 |
541 |
↓2.88 |
catalytic activity |
| 23 |
P06276 |
Cholinesterase |
68418 |
6.92 |
16 |
765 |
↓3.12 |
catalytic activity |
| 24 |
P02652 |
Apolipoprotein A-II |
12520 |
4.74 |
28 |
552 |
↓3.22 |
receptor binding |
| 25 |
O46409 |
Apolipoprotein A-IV |
43294 |
5.74 |
26 |
550 |
↓3.57 |
receptor binding |
| 26 |
Q6Q788 |
Apolipoprotein A-V |
41213 |
4.97 |
13 |
394 |
↓3.59 |
receptor binding |
| 27 | P19875 | Enolase-1 | 47481 | 7.01 | 12 | 252 | ↓5.09 | DNA binding |
* Hepatic fibrosis vs HBV carriers.