Figure 4. Loss of C/ebpβ is insufficient to rescue PHPV like eye phenotype of Tgfβ2 KO mouse.

(A) Representative photomicrographs of hematoxylin- and eosin-stained slides of E15.5 embryos showing the primary vitreous hyperplasia in C/ebpβ^+/+, Tgfβ2^−/− embryos (a) is NOT corrected by additional loss of expression of C/ebpβ in C/ebpβ ^−/−, Tgfβ2^−/− embryos (b-d). Arrows denote the cellular area of the primary vitreous. (B) Quantitative analyses show that the average cell numbers in the vitreous have little change in C/ebpβ ^−/−, Tgfβ2^−/− embryos at E13.5 as compared with C/ebpβ ^+/+, Tgfβ2^−/− littermates.