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Specificity of fluorophore–streptavidin detection of biotinylated total human DNA probe in metaphase chromosomes. (A) Control (no fluorophore–streptavidin conjugate); (B) streptavidin–Qdot 605 detection of chromosome 1q12 region (vertical and horizontal arrows); (C) Texas Red–streptavidin detection of biotinylated DNA hybridized to 1q12 (vertical arrows) and (D) FITC–streptavidin detection of 1q12 sites (vertical arrows). Bar in panel C is 10 µm.
