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. 2013 Aug 5;8(8):e70528. doi: 10.1371/journal.pone.0070528

Figure 5. Effect of free pirfenidone and Pirfenidone NPs on corneal healing after alkali exposure: (A) Representative pictures of control, free pirfenidone and pirfenidone NP treated corneas after 1 hr, 4 th day and 7 th day of alkali treatment.

Figure 5

(B) Corneal re-epithelialization time: Corneal re-epithelialization time was significantly (P<0.05) reduced in pirfenidone NP treated eyes compared to the control eyes, but the corneal re-epithelialization time in free pirfenidone treated eyes was not significantly different from the control eyes. Data is expressed as Mean ± SEM, N = 6. (C) Corneal haze: A significant (P<0.05) reduction in corneal haze score was evidenced in pirfenidone NP treated eyes compared to the control eyes. Data is expressed as Mean ± SEM, N = 6.