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(a) Visible spectra of compound 1 (15 μM) incubated under different conditions: 20 mM Tris.HCl at pH 8.0 (red line), with mNat2 variants (30 μM) in 20 mM Tris.HCl at pH 8.0 (mNat2_WT (light blue line), mNat2_R127G (orange line), mNat2_R127L (green line)) or of compound 1 in 80 mM NaOH at pH 13.75 (dark blue line). (b) Summary of interactions of 1 with hNAT1, mNat2 and the two engineered mNat2 mutants.
